“We Have Our Protector”: Misperceptions of Protection Against HIV Among Participants in a Microbicide Efficacy Trial

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Genital Tenofovir Concentrations Correlate With Protection Against HIV Infection in the CAPRISA 004 Trial: Importance of Adherence for Microbicide Effectiveness.

OBJECTIVE The CAPRISA 004 trial showed that coitally dosed tenofovir 1% gel reduced HIV acquisition by 39% overall and 54% when used consistently. The objective of this analysis was to ascertain its pharmacokinetic-pharmacodynamic relationship to protect against HIV acquisition. DESIGN Genital and systemic tenofovir concentrations in 34 women who acquired HIV (cases) were compared with 302 ra...

متن کامل

Efficacy, Stability, and Biosafety of Sifuvirtide Gel as a Microbicide Candidate against HIV-1

Sifuvirtide is a proven effective HIV-1 entry inhibitor and its safety profile has been established for systemic administration. The present study evaluated the potential of sifuvirtide formulated in a universal gel for topical use as a microbicide candidate for preventing sexual transmission of HIV. Our data showed that sifuvirtide formulated in HEC gel is effective against HIV-1 B, C subtypes...

متن کامل

Using the Tools we Have: Low-efficacy Vaccines and HIV

Article history: Received 10 December 2015 Accepted 10 December 2015 Available online 12 December 2015 ately and maintained for 10 to 30 years, a vaccination policy where the low efficacy vaccine is introduced immediately and switched for a moderate efficacy vaccine when it becomes available 3–8 years later, and a policy where no vaccine is introduced until the moderate efficacy vaccine is avai...

متن کامل

Phase III microbicide trial methodology: opinions of experienced expanded safety trial participants in South Africa.

In preparation for effectiveness trials of candidate vaginal microbicides, scientists are debating trial design and implementation challenges, including choice of control arm(s), product-sharing across arms, and visit schedules. This study involved a survey of South African women participating in an expanded safety trial of the candidate microbicide Carraguard gel. The first 100 consenting wome...

متن کامل

Protection against HIV Acquisition in the RV144 Trial.

Differences of opinion regarding whether there may, or may not, have been protective efficacy in the RV144 vaccine trial have important societal implications.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: American Journal of Public Health

سال: 2006

ISSN: 0090-0036,1541-0048

DOI: 10.2105/ajph.2004.047514